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  • Title: Generation and characterization of a monoclonal IgG antibody to polyethylene glycol.
    Author: Wunderlich DA, Macdougall M, Mierz DV, Toth JG, Buckholz TM, Lumb KJ, Vasavada H.
    Journal: Hybridoma (Larchmt); 2007 Jun; 26(3):168-72. PubMed ID: 17600499.
    Abstract:
    An IgG mouse monoclonal antibody (10F05) against polyethylene glycol has been generated. The antibody reacts with PEG regardless of the linker used for PEG attachment, and is able to recognize a PEGylated peptide in plasma at concentrations as low as 3 pg/mL. The antibody is readily purified in substantial quantities. The PEG IgG will find significant utility in the sensitive detection of PEG derivitives during the pharmacokinetic characterization of PEGylated compounds.
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