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  • Title: Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK.
    Author: Kitagawa H, Ozawa T, Takahata S, Iida M.
    Journal: Bioorg Med Chem Lett; 2007 Sep 01; 17(17):4982-6. PubMed ID: 17600706.
    Abstract:
    Novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae were synthesized and evaluated. Through SAR studies of our initial hit compound 2-(1H-benz[d]imidazol-2-ylthio)-N-(6-methoxycarbonylbenzo[d]thiazol-2-yl)acetamide, a series of novel phenylimidazole derivatives were discovered as potent FabK inhibitors.
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