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  • Title: Molecular design of anti-MRSA agents based on the anacardic acid scaffold.
    Author: Green IR, Tocoli FE, Lee SH, Nihei K, Kubo I.
    Journal: Bioorg Med Chem; 2007 Sep 15; 15(18):6236-41. PubMed ID: 17601740.
    Abstract:
    A series of anacardic acid analogues possessing different side chains viz. phenolic, branched, and alicyclic were synthesized and their antibacterial activity tested against methicillin-resistant Staphylococcus aureus (MRSA). The maximum activity against this bacterium occurred with the branched side-chain analogue, 6-(4',8'-dimethylnonyl)salicylic acid, and the alicyclic side-chain analogue, 6-cyclododecylmethyl salicylic acid, with the minimum inhibitory concentration (MIC) of 0.39 microg/mL, respectively. This activity was superior to that of the most potent antibacterial anacardic acid isolated from the cashew Anacardium occidentale (Anacardiaceae), apple and nut, that is, the 6-[8'(Z),11'(Z),14'-pentadecatrienyl]salicylic acid.
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