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  • Title: Serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy.
    Author: Demirbag R, Yildiz A, Gur M, Yilmaz R, Elçi K, Aksoy N.
    Journal: Clin Biochem; 2007 Sep; 40(13-14):1020-5. PubMed ID: 17604013.
    Abstract:
    OBJECTIVES: The purpose of this study was to determine serum prolidase activity in patients with hypertension and its relation with left ventricular hypertrophy. DESIGN AND METHODS: Serum prolidase activity was measured spectrophotometrically in hypertensive patients with (Group II, n=30) and without left ventricular hypertrophy (Group III, n=30) and in control group (Group I, n=30). RESULTS: Prolidase activity was significantly lower in Group I than in Groups II and III (44.64+/-6.42 U/L vs. 54.14+/-6.30 U/L and 54.25+/-7.14 U/L, respectively; ANOVA, p<0.001). We revealed significant correlation between prolidase activity and presence and duration of hypertension (both of p<0.05) but not left ventricular mass index. Multivariate analysis shown that prolidase activity was significantly associated with age (beta=0.481, p<0.001) and duration of hypertension (beta=0.396, p<0.001). CONCLUSIONS: Our data show that serum prolidase activity is associated with the presence hypertension independent of left ventricular hypertrophy.
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