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  • Title: The primary cilium: keeper of the key to cell division.
    Author: Pan J, Snell W.
    Journal: Cell; 2007 Jun 29; 129(7):1255-7. PubMed ID: 17604715.
    Abstract:
    Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.
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