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  • Title: Use of high-dose ganciclovir for a resistant cytomegalovirus infection due to UL97 mutation.
    Author: West P, Schmiedeskamp M, Neeley H, Oberholzer J, Benedetti E, Kaplan B.
    Journal: Transpl Infect Dis; 2008 Apr; 10(2):129-32. PubMed ID: 17605740.
    Abstract:
    Cytomegalovirus (CMV) infection is a major complication following solid organ transplantation resulting in significant morbidity and mortality. The guidelines published in 2004 have recommendations for therapy; however, the frequency of resistant CMV infection is increasing and therapy is not clearly defined. There are a few alternatives to ganciclovir such as foscarnet, cidofovir, and leflunomide; however, their use is limited by adverse effects. This report summarizes the successful use of high-dose ganciclovir for the treatment of a resistant CMV caused by UL97 mutation.
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