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  • Title: Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult.
    Author: Abbo L, Alcaide ML, Pano JR, Robinson PG, Campo RE.
    Journal: Transpl Infect Dis; 2007 Dec; 9(4):323-6. PubMed ID: 17605748.
    Abstract:
    Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.
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