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  • Title: Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients.
    Author: Chang TY, Chou KJ, Tseng CF, Chung HM, Fang HC, Hung YM, Wu MJ, Tzeng HM, Lind CC, Lu KC.
    Journal: Curr Med Res Opin; 2007 Aug; 23(8):1879-86. PubMed ID: 17605895.
    Abstract:
    OBJECTIVE: Folic acid and vitamin B complex administration in uremic patients has been reported to lower plasma total homocysteine (tHcy) levels, but whether or not this has a beneficial effect on the inflammatory state is not clear. METHODS: We conducted a randomized open labeled study to determine the effects of folic acid (5 mg daily) and vitamin B complex administration on plasma tHcy levels as well as inflammatory (serum high-sensitivity C reactive protein, hs-CRP) and nutritional (serum albumin) markers in patients on maintenance hemodialysis. Treatment was given for 3 consecutive months to 61 patients on maintenance hemodialysis. Another 60 patients, all age-, sex-, hemodialysis duration-matched served as control group. MAIN OUTCOME MEASURES: Plasma tHcy, serum hs-CRP, albumin, creatinine (Cr), post-dialysis body weight (BW), and normalized protein catabolism rate (nPCR). RESULTS: After 3 months, levels of plasma tHcy and serum hs-CRP, Cr, and nPCR were significantly decreased while levels of serum albumin, vitamin B(12), folate, and BW were significantly increased. The dialytic dose (KT/V) and dietary intake remained unchanged. However, correlations between the magnitude of reduction of tHcy & hs-CRP, tHcy & Cr, and Cr & nPCR were statistically significant. CONCLUSIONS: Folic acid and vitamin B complex co-administration effectively lowers tHcy and hs-CRP levels and increases albumin levels in stable hemodialysis subjects, underscoring their potential benefit to attenuate the state of inflammation and possibly improve the nutritional status in patients on hemodialysis.
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