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  • Title: In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.
    Author: Jansen WT, Verel A, Verhoef J, Milatovic D.
    Journal: Antimicrob Agents Chemother; 2007 Sep; 51(9):3420-4. PubMed ID: 17606689.
    Abstract:
    The in vitro activity of telavancin was tested against 620 gram-positive isolates. For staphylococci, MICs at which 50 and 90% of isolates were inhibited (MIC(50) and MIC(90)) were both 0.25 microg/ml, irrespective of methicillin resistance. MIC(50) and MIC(90) were 0.25 and 0.5 microg/ml for vancomycin-susceptible enterococci and 1 and 2 microg/ml for vancomycin-resistant enterococci, respectively. Streptococcus pneumoniae, group A and B beta-hemolytic streptococci, and viridans streptococci were inhibited by < or =0.12 microg/ml.
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