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  • Title: Three loci on mouse chromosome 5 and 10 modulate sex determination in XX Ods/+ mice.
    Author: Poirier C, Moran JL, Kovanci E, Petit DC, Beier DR, Bishop CE.
    Journal: Genesis; 2007 Jul; 45(7):452-5. PubMed ID: 17607692.
    Abstract:
    In mouse, XY embryos are committed to the male sex determination pathway after the transient expression of the Y-linked Sry gene in the Sertoli cell lineage between 10.5 and 12.5 dpc. In the C57BL/6J strain, male sex determination program can be modulated by some autosomal genes. The C57BL/6J alleles at these autosomal loci can antagonize male sex determination in combination with specific Sry alleles. In this report, the authors have identified an effect of these C57BL/6J specific alleles in combination with a mutated Sox9 allele, Sox9(Ods). Authors report the mapping of three of these genetic loci on mouse chromosome 5 and 10 in a backcross of the Ods mutation to the C57BL/6J background. Our study confirms the importance of the strain C57BL/6J for the investigation of the genetic mechanisms that control sex determination.
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