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  • Title: Prenylated xanthones from the root bark of Cudrania tricuspidata.
    Author: Hwang JH, Hong SS, Han XH, Hwang JS, Lee D, Lee H, Yun YP, Kim Y, Ro JS, Hwang BY.
    Journal: J Nat Prod; 2007 Jul; 70(7):1207-9. PubMed ID: 17608532.
    Abstract:
    Four new prenylated xanthones, cudratricusxanthones J-M (1-4), were isolated from the CH2Cl2-soluble extract of the root bark of Cudrania tricuspidata, along with four known prenylated xanthones, isocudraxanthone K (5), cudraxanthone C (6), cudratricusxanthone A (7), and cudraxanthone L (8), and three known prenylated flavonoids, cudraflavone A (9), cudraflavanone A (10), and cudraflavone B (11). The structures of compounds 1-4 were elucidated using spectroscopic methods. Cudratricusxanthone A (7), cudraflavanone A (10), and cudraflavone B (11) showed moderate inhibitory effects on mouse brain monoamine oxidase (MAO) with IC50 values of 88.3, 89.7, and 80.0 microM, respectively.
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