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  • Title: Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis.
    Author: Shen YC, Cheng YB, Lan TW, Liaw CC, Liou SS, Kuo YH, Khalil AT.
    Journal: J Nat Prod; 2007 Jul; 70(7):1139-45. PubMed ID: 17608535.
    Abstract:
    Eight new oxygenated lignans, kadsuphilols A-H (1-8), were isolated from the leaves and stems of Kadsura philippinensis. Four of the isolated lignans (1-4) possess the normal C18-dibenzocyclooctadiene skeleton, while the other four lignans (5-8) are C19-homolignans possessing a substituted cyclohexadienone ring with a spiro-benzofuranoid moiety. The structures of the isolated metabolites were elucidated through spectroscopic analyses, including 2D NMR experiments. Compounds 1 and 4 are the first report of an R-biphenyl configuration with a beta-oxygenated substituent at the C-9 position. The in vitro radical-scavenging activities of these compounds using DPPH were tested and evaluated. Compound 3 exhibited more potent activity than vitamins C and E.
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