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  • Title: 4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors.
    Author: Gaul MD, Xu G, Kirkpatrick J, Ott H, Baumann CA.
    Journal: Bioorg Med Chem Lett; 2007 Sep 01; 17(17):4861-5. PubMed ID: 17611106.
    Abstract:
    A series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF(3) expressed cell line. The structure-activity relationship of this class of compounds is described.
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