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  • Title: Conformationally restrained aromatic analogues of fosmidomycin and FR900098.
    Author: Kurz T, Schlüter K, Pein M, Behrendt C, Bergmann B, Walter RD.
    Journal: Arch Pharm (Weinheim); 2007 Jul; 340(7):339-44. PubMed ID: 17611943.
    Abstract:
    The synthesis and in-vitro antimalarial activity of conformationally restrained bis(pivaloyloxymethyl) ester analogues of the natural product fosmidomycin is presented. In contrast to alpha-aryl-substituted analogues, conformationally restrained aromatic analogues exhibit only moderate in-vitro antimalarial activity against the chloroquine-sensitive strain 3D7 of Plasmodium falciparum. The most active derivative displays an IC(50) value of 47 microM.
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