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Title: A method for reproducibly preparing synthetic nanopores for resistive-pulse biosensors. Author: Wharton JE, Jin P, Sexton LT, Horne LP, Sherrill SA, Mino WK, Martin CR. Journal: Small; 2007 Aug; 3(8):1424-30. PubMed ID: 17615589. Abstract: There is increasing interest in using nanopores in synthetic membranes as resistive-pulse sensors for biomedical analytes. Analytes detected with prototype artificial-nanopore biosensors include drugs, DNA, proteins, and viruses. This field is, however, currently in its infancy. A key question that must be addressed in order for such sensors to progress from an interesting laboratory experiment to practical devices is: Can the artificial-nanopore sensing element be reproducibly prepared? We have been evaluating sensors that employ a conically shaped nanopore prepared by the track-etch method as the sensor element. We describe here a new two-step pore-etching procedure that allows for good reproducibility in nanopore fabrication. In addition, we describe a simple mathematical model that allows us to predict the characteristics of the pore produced given the experimental parameters of the two-step etch. This method and model constitute important steps toward developing practical, real-world, artificial-nanopore biosensors.[Abstract] [Full Text] [Related] [New Search]