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  • Title: Pyridinylimidazole inhibitors of Tie2 kinase.
    Author: Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M.
    Journal: Bioorg Med Chem Lett; 2007 Sep 01; 17(17):4756-60. PubMed ID: 17618114.
    Abstract:
    This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
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