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  • Title: Burkholderia cepacia complex infection in a cohort of Italian patients with cystic fibrosis.
    Author: Lambiase A, Raia V, Stefani S, Sepe A, Ferri P, Buonpensiero P, Rossano F, Del Pezzo M.
    Journal: J Microbiol; 2007 Jun; 45(3):275-9. PubMed ID: 17618236.
    Abstract:
    The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).
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