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  • Title: [Monoamine oxidase inhibitory effects of pentanthrene type heterocyclic compounds].
    Author: Noda A, Noda H, Imamura T, Ono Y, Morita M, Kai M, Mine S, Goto S.
    Journal: Yakugaku Zasshi; 1991 Sep; 111(9):499-503. PubMed ID: 1762051.
    Abstract:
    Pentanthrene type heterocyclic compounds, which contain oxazole, isoxazole, oxadiazole, thiazole, isothiazole, thiadiazole or pyrrole ring as C-ring, and naphthalene, quinoline, isoquinoline or quinoxaline ring as A.B-ring, were prepared, and their monoamine oxidase (MAO) inhibitory activities were examined. As expected from our previous investigation on the structure-activity relationship of this series, most of them showed strong inhibitory potency to both MAO-A and MAO-B. However, a few indicated highly selective inhibition for either of MAO subtypes.
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