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  • Title: [Converse changes in serum levels of immunoglobulins (IgG, A and M) and complement components (C3, 4) during pregnancy].
    Author: Yasuhara M, Tamaki H, Iyama S, Yamaguchi Y, Amino N, Miyai K.
    Journal: Rinsho Byori; 1991 Nov; 39(11):1195-8. PubMed ID: 1762197.
    Abstract:
    Sequential changes in serum levels of the immunoglobulins IgG, A and M and of the complements C3 and C4 during pregnancy and the postpartum period were studied in 8 healthy women. Serum IgG and A levels decreased gradually during pregnancy, but increased significantly during the first three months following delivery. Serum IgM level also decreased during pregnancy, reaching its minimum during the second trimester, but increased thereafter. In contrast, C3 and C4 levels increased significantly during pregnancy and reached their maximum levels during the last trimester. After delivery, levels of these two components decreased gradually for the next six months. The complement system may operate as a compensatory autoregulatory mechanism in the suppression of the humoral immune system during pregnancy.
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