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  • Title: [The antiphlogistic effect of the ginkgolide BN 52 021 in the chemically burned rabbit eye].
    Author: Struck HG, Geiser H, Taube C, Block HU, Mest HJ, Tost M.
    Journal: Klin Monbl Augenheilkd; 1991 Oct; 199(4):278-82. PubMed ID: 1762355.
    Abstract:
    BN 52 021, a specific antagonist of PAF receptors, was tested in the early-phase treatment of chemically burned eyes in 30 rabbits. The local application of BN 52 021 eyedrops-1% (water-soluble preparation, 5 times daily, in comparison with the other eye as a control) led to a visible anti-inflammatory effect (microscopically and macroscopically) of the chemically burned anterior eye segment. There was only a moderate increase of the concentration of PGF2 alpha after the chemical burn. The use of specific PAF antagonists seems to have a real chance for treatment of inflammatory reactions of the anterior eye segment. A combination with other mediator antagonists should be tested in further experiments.
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