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  • Title: Androgenic juvenile granulosa cell tumor of the ovary with cystic presentation: a case report.
    Author: Nomelini RS, Micheletti AM, Adad SJ, Murta EF.
    Journal: Eur J Gynaecol Oncol; 2007; 28(3):236-8. PubMed ID: 17624097.
    Abstract:
    Granulosa cell tumors account for approximately 1-2% of all ovarian tumors. There are two types: adult granulosa cell tumor and juvenile granulosa cell tumor. Juvenile granulosa cell tumors constitute 5% of this histological subtype, and the prognosis is good because the majority present as Stage I tumors. The treatment can consist of conservative surgery. Androgen production is rare and produces virilization in women. These tumors are usually solid or predominantly solid. We describe the case of a 13-year-old girl with androgenic manifestations and increased abdominal size. Her plasma testosterone level was elevated. A left adnexal cyst (14.4 x 9.1 x 9.7 cm) was revealed at pelvic ultrasonography. The patient underwent an exploratory laparotomy, revealing a left ovarian cystic tumor. Diagnosis was juvenile granulosa cell tumor.
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