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  • Title: Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.
    Author: Li HQ, Xue JY, Shi L, Gui SY, Zhu HL.
    Journal: Eur J Med Chem; 2008 Mar; 43(3):662-7. PubMed ID: 17624635.
    Abstract:
    A series of deoxybenzoin derivatives from genistein were synthesized and their structures were elucidated by (1)H NMR, mass spectral data and micro analyses. The structures of 2, 7 and 10 were determined by single-crystal X-ray analysis. These obtained compounds were evaluated for their assayed antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Most compounds have displayed comparable antibacterial activity against bacterial. On the basis of the biological results, structure-activity relationships are discussed.
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