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  • Title: The insulin-like growth factor 1 receptor in cancer: old focus, new future.
    Author: Hartog H, Wesseling J, Boezen HM, van der Graaf WT.
    Journal: Eur J Cancer; 2007 Sep; 43(13):1895-904. PubMed ID: 17624760.
    Abstract:
    The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour of tumour cells is well established. Currently, development of drugs targeting the IGF-1R as anticancer treatment is emerging. Several IGF-1R targeting strategies are being investigated in phases I and II clinical trials. Interactions of IGF-1R with insulin receptor, however, might complicate efficiency and tolerability of such drugs. This review describes mechanisms, recent developments and potential limitations of IGF-1R antibodies and tyrosine kinase inhibitors.
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