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  • Title: Inhibitory action of acetylcholine, baclofen and GTP-gamma-S on calcium channels in adult rat sensory neurons.
    Author: Formenti A, Sansone V.
    Journal: Neurosci Lett; 1991 Oct 14; 131(2):267-72. PubMed ID: 1762700.
    Abstract:
    High- and low-voltage activated calcium channel currents (HVA and LVA) were inhibited by acetylcholine (10-100 microM) and baclofen (10 microM) in adult rat sensory neurons. This modulatory effect was present on dihydropyridine (nifedipine 1 microM) and/or omega-conotoxin (3.2 microM, 2-5 h incubation) insensitive components and was insensitive to holding potentials (Vh -50 to -90 mV). GTP-gamma-S (100 microM) prolonged calcium channel current activation in a time- and voltage-dependent manner. On the other hand, the current amplitude reduction induced by muscarinic and GABAB receptor activation, was not relieved by a 50-ms conditioning prepulse to +50 mV. This suggests the possibility of an alternative voltage-independent modulation mechanism.
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