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  • Title: Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.
    Author: Bouchikhi F, Anizon F, Moreau P.
    Journal: Eur J Med Chem; 2008 Apr; 43(4):755-62. PubMed ID: 17628214.
    Abstract:
    In the course of structure-activity relationship studies, diversely substituted 1-(beta- d-acetylatedglucopyranosyl)isoindigo derivatives were prepared from indolines. New 7'-azaisoindigo analogues were also synthesized by coupling a glycosylated isatine and a 7-azaindolin-2-one derivative. Compounds containing a 7'-azaisoindigo framework have never been described before. To get an insight into the substitution pattern required for the best biological potencies, their antiproliferative activities were evaluated toward a human buccal carcinoma cell line (KB) and two human myeloid leukaemia cell lines (K562, HL60).
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