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  • Title: [The vaccination of children with allergic diseases with reduced doses of adsorbed DT-m anatoxin].
    Author: Kostinov MP, Balabolkin II, Maksimova NM, Gervazieva VB, Egor'kov NA, Ovsiannikova IG, Lobanova AN.
    Journal: Pediatriia; 1991; (8):26-33. PubMed ID: 1762853.
    Abstract:
    During a remission and drug therapy, 71 children suffering from allergic diseases were vaccinated with DT-M toxoid containing different dose of diphtheria (1, 2.5, 5 LF) and tetanus (1, 2.5, 5 EC) antigens. It has been shown that all the children responded to tetanus antigen by adequate serological tests, whereas as regards diphtheria toxoid, the patients immunized with the least dose of DT-M preparation (1 LF + + 1 EC antigens) produced specific antibodies later and at a lower level. During the postvaccinal period, they also manifested an increase of the content of IgE and exacerbation of the underlying disease in 17.8% of cases. The use of DT-M toxoid with 2.5 LF + EC antigens was shown to hold promise in vaccination of children suffering from allergic diseases.
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