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  • Title: Effects of central injection of L-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats.
    Author: Tanida M, Gotoh H, Taniguchi H, Otani H, Shen J, Nakamura T, Tsuruoka N, Kiso Y, Okumura N, Nagai K.
    Journal: Regul Pept; 2007 Dec 04; 144(1-3):62-71. PubMed ID: 17628717.
    Abstract:
    In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT). We found that injection of a low dose of L-carnosine (0.01 microg) suppressed BAT-SNA significantly. Conversely, a high dose (100 microg) of L-carnosine significantly elevated BAT-SNA. In the light period (14:00), brown adipose tissue temperature (BAT-T) and BT were suppressed after low and elevated after high dose injection of L-carnosine whereas in the dark period (2:00), these parameters remained unchanged with L-carnosine treatment. Bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolished the effects of low and high doses of L-carnosine on BAT-SNA, BAT-T and BT. Furthermore, high dose treatment with L-carnosine altered c-Fos induction in the SCN and the PVN. These results suggest that l-carnosine affects BAT-SNA, BAT-T and BT in a dose-dependent manner in the rat, and that the SCN may be involved in these effects.
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