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  • Title: [Changes in expression of gelatinase in young rat condylar cartilage during functional mandibular advancement].
    Author: Wang YM, Wang SG, Zhou L, Chen YX.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 2007 Jun; 25(3):299-301, 305. PubMed ID: 17629213.
    Abstract:
    OBJECTIVE: To investigate the changes in expression of gelatinase (MMP-2, MMP-9) in young rat condylar cartilage during functional mandibular advancement. METHODS: Sixty male 5-week old SD rats were divided into experimental and control groups. The mimic functional appliances were used in experimental group rats. The animals were sacrificed after 1, 2, 4 weeks. The immunoreactivity of gelatinase was detected by immunohistochemistry. RESULTS: In normal mandibular condylar cartilage, the immunoreactivity of MMP-2 was rather strong, the immunoreactivity of MMP-9 was very weak. Following functional mandibular advancement, the expression of MMP-9 was significantly increased (P < 0.01), but immunoreactivity of MMP-2 had no significant changes. CONCLUSION: Gelatinase plays an important role in the adaptive remondling of young rat condylar cartilage during functional mandibular advancement.
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