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  • Title: Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART.
    Author: Björkman P, Flamholc L, Molnegren V, Marshall A, Güner N, Widell A.
    Journal: AIDS; 2007 Jul 31; 21(12):1641-3. PubMed ID: 17630561.
    Abstract:
    In patients co-infected with HIV-1 and GB virus C (GBV-C), the disappearance of GBV-C RNA has been associated with accelerated disease progression. We studied longitudinal GBV-C viral titres in 28 HIV-1/GVB-C co-infected individuals receiving HAART. During HAART, median GBV-C RNA titres increased from 95 to 6000 copies/ml (P < 0.001). In patients interrupting HAART, GBV-C-RNA titres decreased as HIV replication resumed. These findings further support the theory that GBV-C replication could depend on the dynamics of HIV progression.
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