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  • Title: Eosinophilic oesophagitis and coeliac disease: is there an association?
    Author: Quaglietta L, Coccorullo P, Miele E, Pascarella F, Troncone R, Staiano A.
    Journal: Aliment Pharmacol Ther; 2007 Aug 01; 26(3):487-93. PubMed ID: 17635383.
    Abstract:
    AIM: To report a series of 17 children affected by eosinophilic oesophagitis. Six of them also received a diagnosis of coeliac disease. METHODS: Seventeen children with history of dyspeptic symptoms were investigated. RESULTS: Six patients (M/F:2/4; mean age +/- s.d.: 5.6 +/- 1.3 years, range: 4-7 years; Group A) affected by eosinophilic oesophagitis also received a diagnosis of coeliac disease. The other 11 children (M/F:10/1, mean age +/- s.d.:7.5 +/- 2.3 years, range: 4-10 years, Group B) were affected solely by eosinophilic oesophagitis. All children underwent a change in dietary regimen. Group A received a gluten-free diet. Group B attempted dietary restriction based on the allergy testing results. After 6 months follow-up, all patients in Group A showed a complete disappearance of symptoms and three of them, who underwent upper gastrointestinal endoscopy, showed histologic remission. Patients from Group B had moderate clinical improvement and in seven of them (64%) a repeated upper gastrointestinal endoscopy showed a statistically significant reduction in eosinophilic infiltration. CONCLUSIONS: This is the first reported group of patients with an association between coeliac disease and eosinophilic oesophagitis. To date, it is not possible to exclude that in a subgroup of children with coeliac disease the oesophageal eosinophilic infiltration could be caused by coeliac disease itself.
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