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  • Title: Prevention of endotoxin-induced increase of cerebral oxygen consumption in dogs by propranolol pretreatment.
    Author: Westerlind A, Larsson LE, Häggendal J, Ekström-Jodal B.
    Journal: Acta Anaesthesiol Scand; 1991 Nov; 35(8):745-9. PubMed ID: 1763594.
    Abstract:
    Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) were studied in experimental endotoxic shock in dogs. Eight animals were pretreated with a beta-adrenoceptor blocking agent, propranolol (PPL), per os 12 mg/kg once a day for 7 days. Ten animals served as controls. After an intravenous injection of endotoxin, 1 mg/kg, CBF decreased in both groups, with no significant differences between the groups. CMRO2 increased in the control animals by about 18% from the baseline value both 1 and 2 h after the injection of endotoxin. CMRO2 in the PPL-pretreated animals was unchanged after endotoxin. The CMRO2-reactions to endotoxin in control and PPL animals were significantly different after both 1 and 2 h (P less than 0.05). The present results indicate that the increase in CMRO2 following intravenous endotoxin is mediated via beta-adrenoceptors.
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