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  • Title: Synthesis and antimalarial properties of new chloro-9H-xanthones with an aminoalkyl side chain.
    Author: Portela C, Afonso CM, Pinto MM, Lopes D, Nogueira F, do Rosário V.
    Journal: Chem Biodivers; 2007 Jul; 4(7):1508-19. PubMed ID: 17638332.
    Abstract:
    The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2-(diethylamino)ethyl]amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-1-{[2-(diethylamino)ethyl]amino}-9H-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50 = 3.9 microM) towards the resistant Dd2 strain.
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