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  • Title: [Use of flecainide in the preventive treatment of tachycardia crisis of Wolff-Parkinson-White syndrome in 4 newborn infants].
    Author: Lupoglazoff JM, Jacqz-Aigrain E, Denjoy I, Casasoprana A.
    Journal: Arch Fr Pediatr; 1991 Nov; 48(9):627-9. PubMed ID: 1763931.
    Abstract:
    Four neonates with Wolff-Parkinson-White syndrome developed supraventricular tachycardia and received flecainide orally after reduction of the arrhythmia. The initial doses were 5 mg/kg/day. They are increased according to clinical response and flecainide concentrations, with 5 and 10 mg/kg/24 h respectively, were in the therapeutic range of 200 to 1000 micrograms/l. Flecainide was effective and well tolerated in the 4 cases. Therefore, this drug may be an alternative to digoxine to prevent supraventricular tachycardias in the neonatal period.
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