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  • Title: Synthesis of new benzimidazole derivatives as potential antimicrobial agents.
    Author: Badawey ES, Hassan AM, Kappe T.
    Journal: Arch Pharm (Weinheim); 1991 Jun; 324(6):355-7. PubMed ID: 1763947.
    Abstract:
    Barbiturates 3 as possible antimicrobial agents were obtained by reacting the N,N'-disubstituted urea 1a or the thiourea analogues 1b,c with the magic malonates 2a,b. On the other hand, reaction of 1a with ethoxycarbonyl isocyanate (4) yielded the substituted s-triazine-2,4,6(1H,3H,5H)-trione 5. The reaction of 4 with 2-aminomethyl-benzimidazole (6) gave the allophanate 7 which upon treatment with Na2CO3 yielded N-(1H-benzimidazol-2-yl)urea 8.
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