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  • Title: [Preparation and quality evaluation of quercetin self-emulsifyied drug delivery systems].
    Author: Hu Y, Chen HL, Liang WQ.
    Journal: Zhongguo Zhong Yao Za Zhi; 2007 May; 32(9):805-7. PubMed ID: 17639979.
    Abstract:
    OBJECTIVE: To prepare the quercetin self-emulsified formulation and evaluate its quality. METHOD: The quercetin self-emulsified formulation was optimized based on the quercetin solubility in different oils, and the self-microemulsified efficiency of various combinations of emulsifier and co-emulsifier evaluated using the pseudo-ternary phase diagram. The microemulsion of morphology, size and zeta potential were examined. The quercetin of solubility in self-emulsified system was tested and the formulation stability was investigated by accelerated experiment. RESULT: The blank self-emulsified system was composed of ethyl oleate/Cremophor EUL/butanol with weight ratio of 10: 54: 36. After being dilutied with water, the morphology of microemulsion was homogeneous small spherical drops observed under the electro-microscopy. The particle size and the zeta potential were 16.3 +/- 4.6 nm and 2.1 +/- 0.8 mV, respectively. The solubility of quercetin in self-emulsifing system was (62.42 +/- 0.11) mg x mL(-1), increased 2 229 folds compared with that of in water. The quality of quercetin self-emulsified formulation was stable during the 3 months storage at 40 degrees C. CONCLUSION: The solubility of quercetin is significantly increased in self-emulsified system and the formulation is stable and easy to prepare.
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