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  • Title: Serum interleukin-6 in patients with burning mouth syndrome and relationship with depression and perceived pain.
    Author: Chen Q, Xia J, Lin M, Zhou H, Li B.
    Journal: Mediators Inflamm; 2007; 2007():45327. PubMed ID: 17641729.
    Abstract:
    OBJECTIVE: To examine alteration of serum interleukin-6 and its clinical significance in burning mouth syndrome (BMS) patients. METHODS: 48 BMS patients and 31 healthy controls participated in the study. Serum interleukin-6 was measured by means of ELISA. Hamilton rating scale of depression (HRSD) and visual analogue scale (VAS) were used to quantitate depressive status and pain levels of subjects, respectively. RESULTS: 15 (31%) patients displayed substantial depressive symptoms (HRSD > or = 16). HRSD scores of patients were significantly higher than controls and positively correlated to their VAS values (P = .002). Serum interleukin-6 in patients was much lower than controls and negatively correlated to their VAS values (P = .011). However, no significant relations were found between interleukin-6 and HRSD scores (P = .317). CONCLUSIONS: Serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain. Both psychological and neuropathic disorders might act as precipitating factors in BMS etiopathogenesis.
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