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  • Title: CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.
    Author: Kim H, Huang J, Chen J.
    Journal: Nat Struct Mol Biol; 2007 Aug; 14(8):710-5. PubMed ID: 17643122.
    Abstract:
    The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.
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