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  • Title: The underestimated risk of hepatitis A and hepatitis B: benefits of an accelerated vaccination schedule.
    Author: Keystone JS, Hershey JH.
    Journal: Int J Infect Dis; 2008 Jan; 12(1):3-11. PubMed ID: 17643334.
    Abstract:
    Hepatitis A virus (HAV) and hepatitis B virus (HBV) are vaccine-preventable. Current recommendations advocate vaccination of non-immune adults at risk of exposure, including travelers to HAV or HBV endemic areas, individuals with high risk of contracting a sexually transmitted infection, and some correctional facility inmates. We review the use of an accelerated schedule to administer the combination hepatitis A and hepatitis B vaccine (Twinrix). Administering three doses over three weeks and a fourth at 12 months provides rapid initial protection of most individuals for whom the standard 6-month vaccination schedule would not be suitable, including last-minute travelers and short-term correctional facility inmates. Furthermore, we consider the role of a universal vaccination strategy in preventing the spread of HAV and HBV.
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