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  • Title: Metallic stent placement in the palliative treatment of malignant gastroduodenal obstructions: prospective evaluation of results and factors influencing outcome in 213 patients.
    Author: Kim JH, Song HY, Shin JH, Choi E, Kim TW, Jung HY, Lee GH, Lee SK, Kim MH, Ryu MH, Kang YK, Kim BS, Yook JH.
    Journal: Gastrointest Endosc; 2007 Aug; 66(2):256-64. PubMed ID: 17643698.
    Abstract:
    BACKGROUND: Metallic stents are a therapeutic option for patients with malignant GI obstruction. OBJECTIVE: Our purpose was to evaluate the clinical effectiveness of a self-expandable metallic stent in 213 patients with malignant gastroduodenal obstruction and to identify prognostic factors associated with clinical outcomes. DESIGN: Prospective cohort study. SETTING: Single tertiary referral university hospital. PATIENTS: Two hundred thirteen consecutive patients with symptomatic malignant gastric outlet or duodenal obstruction from 2001 to 2005. INTERVENTIONS: Placement of a self-expandable metallic stent. MAIN OUTCOME MEASUREMENTS: Prospective data collection focused on technical and clinical success, complications, and prognostic factors associated with stent patency. RESULTS: Technical and clinical success were achieved in 94% and 94% of the patients, respectively, and the complication rate was 21%. The median and mean survival periods were 99 (95% CI, 78-121) and 159 days (95% CI, 116-203). The median and mean stent patency periods were 270 (95% CI, 234-413) and 324 days (95% CI, 128-412). With use of the multivariate Cox proportional hazard model, chemotherapy after stent placement (odds ratio, 0.19; 95% CI, 0.08-0.46; P < .001) was significantly associated with an increase in the maintenance of stent patency. LIMITATIONS: Single-center experience and the lack of a control group. CONCLUSIONS: Placement of a self-expandable metallic stent is clinically effective in patients with unresectable gastric outlet or duodenal obstruction. Chemotherapy after stent placement, albeit associated with increased migration rates, is associated with an increase in the maintenance of stent patency.
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