These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Strategies to establish left/right asymmetry in vertebrates and invertebrates.
    Author: Spéder P, Petzoldt A, Suzanne M, Noselli S.
    Journal: Curr Opin Genet Dev; 2007 Aug; 17(4):351-8. PubMed ID: 17643981.
    Abstract:
    Left/right (L/R) asymmetry is essential during embryonic development for organ positioning, looping and handed morphogenesis. A major goal in the field is to understand how embryos initially determine their left and right hand sides, a process known as symmetry breaking. A number of recent studies on several vertebrate and invertebrate model organisms have provided a more complex view on how L/R asymmetry is established, revealing an apparent partition between deuterostomes and protostomes. In deuterostomes, nodal cilia represent a conserved symmetry-breaking process; nevertheless, growing evidence shows the existence of pre-cilia L/R asymmetries involving active ion flows. In protostomes like snails and Drosophila, symmetry breaking relies on different mechanisms, involving, in particular, the actin cytoskeleton and associated molecular motors.
    [Abstract] [Full Text] [Related] [New Search]