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  • Title: Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.
    Author: Musonda CC, Little S, Yardley V, Chibale K.
    Journal: Bioorg Med Chem Lett; 2007 Sep 01; 17(17):4733-6. PubMed ID: 17644333.
    Abstract:
    The synthesis and antimalarial activity of a novel series of first generation 4-aminoquinoline-containing 2,4,5-trisubstituted aminoxazoles against two strains of the Plasmodium falciparum parasite in vitro is described. A number of compounds significantly more potent than the standard drug chloroquine were identified.
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