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  • Title: Mechanisms that mediate stem cell self-renewal and differentiation.
    Author: Zhang H, Wang ZZ.
    Journal: J Cell Biochem; 2008 Feb 15; 103(3):709-18. PubMed ID: 17647265.
    Abstract:
    Stem cells have two common properties: the capacity for self-renewal and the potential to differentiate into one or more specialized cell types. In general, stem cells can be divided into two broad categories: adult (somatic) stem cells and embryonic stem cells. Recent evidence suggested that tumors may contain "cancer stem cells" with indefinite potential for self-renewal. In this review, we will focus on the molecular mechanisms regulating embryonic stem cell self-renewal and differentiation, and discuss how these mechanisms may be relevant in cancer cells.
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