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  • Title: The association between cognition and functional outcome in first-episode patients with schizophrenia: mystery resolved?
    Author: van Winkel R, Myin-Germeys I, De Hert M, Delespaul P, Peuskens J, van Os J.
    Journal: Acta Psychiatr Scand; 2007 Aug; 116(2):119-24. PubMed ID: 17650273.
    Abstract:
    OBJECTIVE: The presence of a prospective association between cognition and functional outcome in first episode patients with schizophrenia is much debated. METHOD: Associations between Intelligence Quotient (IQ) measures and functional outcome were assessed at the first hospitalization and after 10 years follow-up. RESULTS: Functional outcome was associated with estimated premorbid IQ and IQ at 10-year follow-up, but not with IQ assessed at first hospitalization. CONCLUSION: The presence of a prospective as well as a cross-sectional relationship of the global cognitive measure IQ with 10-year functional outcome could be established. However, assessing associations between cognitive measures assessed at first hospitalization and subsequent functional outcome, can give inconclusive results due to non-uniform intellectual deterioration from premorbid level in the period preceding the first hospitalization.
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