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  • Title: Association of novel promoter single nucleotide polymorphisms in vasopressin V1a receptor gene with essential hypertension in nonobese Japanese.
    Author: Hasan KN, Shoji M, Sugimoto K, Tsutaya S, Matsuda E, Kudo R, Nakaji S, Suda T, Yasujima M.
    Journal: J Hum Hypertens; 2007 Oct; 21(10):825-7. PubMed ID: 17653244.
    Abstract:
    We studied the association between four novel single nucleotide polymorphisms (SNPs) in the promoter region of V1aR gene and essential hypertension in 620 Japanese subjects (365 hypertensives and 255 healthy). A significant association was found between one of the genotypes and alleles at SNP -6951 and hypertension in a subsample of nonobese individuals. This association demonstrated an independent risk for nonobese hypertension.
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