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  • Title: Nalorphine: increased sensitivity of monkeys formerly dependent on morphine.
    Author: Goldberg SR, Schuster CR.
    Journal: Science; 1969 Dec 19; 166(3912):1548-9. PubMed ID: 17655059.
    Abstract:
    Three rhesus monkeys Macaca mulatta, formerly dependent on morphine, had increased sensitivity to nalorphine's effect of suppressing operant responding for food, as compared with two monkeys with no history of morphine exposure. Within the dose range employed, nalorphine injections produced emesis, salivation, and hyperirritability in formerly morphine-dependent monkeys but not in controls.
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