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  • Title: Three-dimensional Monte Carlo simulations of intracellular diffusion and reaction of signaling proteins.
    Author: Zhdanov VP.
    Journal: J Chem Phys; 2007 Jul 21; 127(3):035101. PubMed ID: 17655463.
    Abstract:
    We show that the Monte Carlo technique makes it possible to perform three-dimensional simulations of intracellular protein-mediated signal transduction with realistic ratio of the rates of protein diffusion and association with genes. Specifically, we illustrate that in the simplest case when the protein degradation and phosphorylation/dephosphorylation are negligible the distribution of the first passage time for this process is close to exponential provided that the number of target genes is between 1 and 100.
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