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  • Title: Nanoparticle-based electrochemical detection of hepatitis B virus using stripping chronopotentiometry.
    Author: Hanaee H, Ghourchian H, Ziaee AA.
    Journal: Anal Biochem; 2007 Nov 15; 370(2):195-200. PubMed ID: 17655817.
    Abstract:
    A selective and sensitive gold nanoparticle-based electrochemical method for detection of hepatitis B virus DNA sequences was used. This method relies on the hybridization of amplified hepatitis B virus DNA strands with probes that are extended on paramagnetic beads. After separation of noncomplementary sequences, hybridized magnetic beads were treated with streptavidin-modified gold followed by silver enhancement. High selectivity and high sensitivity were obtained using electrochemical stripping detection of silver ions that were deposited on gold nanoparticles. With a signal/noise ratio of approximately 4.6, the detection limit was estimated to be 0.7ng/ml.
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