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  • Title: 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil.
    Author: Osorio JA, Ozturk-Isik E, Xu D, Cha S, Chang S, Berger MS, Vigneron DB, Nelson SJ.
    Journal: J Magn Reson Imaging; 2007 Jul; 26(1):23-30. PubMed ID: 17659562.
    Abstract:
    PURPOSE: To implement proton magnetic resonance spectroscopic imaging (1H MRSI) at 3 Tesla (3T) using an eight-channel phased-array head coil in a population of brain-tumor patients. MATERIALS AND METHODS: A total of 49 MRI/MRSI examinations were performed on seven volunteers and 34 patients on a 3T GE Signa EXCITE scanner using body coil excitation and reception with an eight-channel phased-array head coil. 1H MRSI was acquired using point-resolved spectroscopy (PRESS) volume selection and three-dimensional (3D) phase encoding using a 144-msec echo time (TE). RESULTS: The mean choline to N-acetyl aspartate ratio (Cho/NAA) was similar within regions of normal-appearing white matter (NAWM) in volunteers (0.5 +/- 0.04) and patients (0.6 +/- 0.1, P = 0.15). This ratio was significantly higher in regions of T2-hyperintensity lesion (T2L) relative to NAWM for patients (1.4 +/- 0.7, P = 0.001). The differences between metabolite intensities in lesions and NAWM were similar, but there was an increase in SNR of 1.95 when an eight-channel head coil was used at 3T vs. previous results at 1.5T. CONCLUSION: The realized increase in SNR means that clinically relevant data can be obtained in five to 10 minutes at 3T and used to predict the spatial extent of tumor in a manner similar to that previously used to acquire 1.5T data in 17 minutes.
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