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  • Title: Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.
    Author: Graninger WB, Hassfeld W, Pesau BB, Machold KP, Zielinski CC, Smolen JS.
    Journal: J Rheumatol; 1991 Oct; 18(10):1621-2. PubMed ID: 1765991.
    Abstract:
    The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis. In addition to glomerulonephritis and a butterfly rash, previously negative tests for antinuclear, anti-dsDNA and anti-Sm antibodies became positive. We assume that rIFN-gamma induced the de novo development of SLE in our patient.
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