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  • Title: [Cardiovascular toxicity of selective COX-2-inhibitors and classical NSAIDs].
    Author: Lange H, Eberhart L.
    Journal: Anasthesiol Intensivmed Notfallmed Schmerzther; 2007 Jul; 42(7):514-7. PubMed ID: 17661262.
    Abstract:
    Concerning the current discussion about cardiovascular toxicity of the selective COX-2 inhibitors, recently advertised in the media as a new milestone in the management of pain, culminating in the market withdrawal of the preparations Vioxx (rofecoxib) in 2004 and Bextra (valdecoxib) in 2005, the classical NSAIDs are now spotlighted. How safe are the "well established" NSAIDs regarding adverse cardiovascular events? Long term studies now show a similar overall risk compared to the selective COX-2 inhibitors. The short lasting perioperative administration of both drug classes are still indicated. However, even here they should be only used after a systematic risk-calculation and not on a routine basis.
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